Cucurbit[6]uril (CB6) is a well-known hyperpolarized 129Xe (HP 129Xe) MRI contrast agent. Although in-vivo biodistribution detection of CB6 has already been achieved, no studies have been performed on optimization of the saturation pre-pulse train in order to maximize CB6 performance. In the present work, we demonstrate that utilization of sinusoidal saturation pulses for 129Xe HyperCEST MRI, instead of using conventional three-lobe sinc pulses, yields substantial improvement of CB6 HyperCEST performance and a significant increase in HyperCEST MRI sensitivity. In addition, lower detectable CB6 concentrations are reported for both types of saturation pre-pulses at 3T using a whole-body scanner.
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