Abstract #3572

Saturation pre-pulse train optimization for maximization of cucurbit[6]uril hyperpolarized chemical exchange saturation transfer at 3.0 T

Vira Grynko^1,2, Yurii Shepelytskyi^2,3, Tao Li³, Hannah Aalto⁴, Iulian Constantin Ruset⁵, and Mitchell S Albert^2,3,6

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry Department, Lakehead University, Thunder Bay, ON, Canada, ⁴Applied Life Science Program, Lakehead University, Thunder Bay, ON, Canada, ⁵Xemed LLC, Durham, NH, United States, ⁶Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Synopsis

Cucurbit[6]uril (CB6) is a well-known hyperpolarized ¹²⁹Xe (HP ¹²⁹Xe) MRI contrast agent. Although in-vivo biodistribution detection of CB6 has already been achieved, no studies have been performed on optimization of the saturation pre-pulse train in order to maximize CB6 performance. In the present work, we demonstrate that utilization of sinusoidal saturation pulses for ¹²⁹Xe HyperCEST MRI, instead of using conventional three-lobe sinc pulses, yields substantial improvement of CB6 HyperCEST performance and a significant increase in HyperCEST MRI sensitivity. In addition, lower detectable CB6 concentrations are reported for both types of saturation pre-pulses at 3T using a whole-body scanner.

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