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Abstract #3572

Saturation pre-pulse train optimization for maximization of cucurbit[6]uril hyperpolarized chemical exchange saturation transfer at 3.0 T 

Vira Grynko1,2, Yurii Shepelytskyi2,3, Tao Li3, Hannah Aalto4, Iulian Constantin Ruset5, and Mitchell S Albert2,3,6
1Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Chemistry Department, Lakehead University, Thunder Bay, ON, Canada, 4Applied Life Science Program, Lakehead University, Thunder Bay, ON, Canada, 5Xemed LLC, Durham, NH, United States, 6Northern Ontario School of Medicine, Thunder Bay, ON, Canada


Cucurbit[6]uril (CB6) is a well-known hyperpolarized 129Xe (HP 129Xe) MRI contrast agent. Although in-vivo biodistribution detection of CB6 has already been achieved, no studies have been performed on optimization of the saturation pre-pulse train in order to maximize CB6 performance. In the present work, we demonstrate that utilization of sinusoidal saturation pulses for 129Xe HyperCEST MRI, instead of using conventional three-lobe sinc pulses, yields substantial improvement of CB6 HyperCEST performance and a significant increase in HyperCEST MRI sensitivity. In addition, lower detectable CB6 concentrations are reported for both types of saturation pre-pulses at 3T using a whole-body scanner.

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