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Abstract #3587

Differences in brain metabolites in awake and anesthetized mice revealed by 1H-MRS

Ren Li1, Wenjing Xu1, Zhifeng Liang2, and Xiao-Yong Zhang1
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Institute of Neuroscience, CAS Center for Excellence in Brain Sciences and Intelligence Technology, Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, China


It is important to investigate neural metabolism and brain functions in awake animals for preclinical studies. However, there are few magnetic resonance spectroscopy (MRS) studies in rodents under awake conditions. In this work, we developed an MRI-compatible restraint device for the measurement of brain metabolism in awake mice. Using 1H-MRS, we successfully observed the brain metabolic profile of prefrontal cortex and thalamus in awake mice. In addition, we found metabolic alterations between awake and anesthetized states, indicating that anesthesia has a non-negligible impact on brain metabolism.

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