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Abstract #3588

Assessment of the correlation between blood perfusion and protein contents in brain of healthy subjects

Fan Yu1, Qiuxuan Li1, Cheng Zhao1, Liangjie Lin2, Jiazheng Wang2, and Jie Lu1
1Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, 2Philips Healthcare, Beijing, China, Beijing, China

Synopsis

The blood perfusion and protein contents in brain of healthy subjects were measured in this study by 3D pseudo continuous arterial spin labeling and 3D amide proton transfer weighted imaging. Results showed a negative correlation between blood perfusion and the content of mobile cellular proteins and peptides in brain of heathy subjects; and the blood perfusion in normal brain, rather than the protein content, showed a significant dependence to age.

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