Abstract #3589

Non-invasive MRI measures of glymphatic system activity associated with CSF-Aβ and FDG-PET uptakes in Alzheimer’s disease

Koji Kamagata¹, Christina Andica¹, Kaito Takabayashi¹, Yuya Saito¹, Toshiaki Taoka², Hayato Nozaki¹, Junko Kikuta¹, Shohei Fujita¹, Kouhei Kamiya³, Akihiko Wada¹, Toshiaki Akashi¹, Masaaki Hori³, Shinji Naganawa², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, Nagoya University, Aichi, Japan, ³Department of Radiology, Toho University, Tokyo, Japan

Synopsis

We assessed the non-invasive MRI measurements, such as the diffusivity along the perivascular space (PVS) represented by ALPS index, PVS volume, and fractional volume of free water in the white matter (FW-WM), in cognitively normal subjects and subjects with Alzheimer’s disease (AD) or mild cognitive impairment (MCI). Abnormalities were detected in the subjects with AD and MCI, and theirALPS index and FW-WM values were significantly associated with CSF Aβ levels and FDG PET uptake, as well as with multiple cognitive scores, thus suggesting that a glymphatic system dysfunction could be associated with Aβ deposition and cognitive impairments.

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