Non-invasive MRI measures of glymphatic system activity associated with CSF-Aβ and FDG-PET uptakes in Alzheimer’s disease
Koji Kamagata1, Christina Andica1, Kaito Takabayashi1, Yuya Saito1, Toshiaki Taoka2, Hayato Nozaki1, Junko Kikuta1, Shohei Fujita1, Kouhei Kamiya3, Akihiko Wada1, Toshiaki Akashi1, Masaaki Hori3, Shinji Naganawa2, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, Nagoya University, Aichi, Japan, 3Department of Radiology, Toho University, Tokyo, Japan
We assessed the non-invasive MRI measurements, such as the diffusivity along the perivascular space (PVS) represented by ALPS index, PVS volume, and fractional volume of free water in the white matter (FW-WM), in cognitively normal subjects and subjects with Alzheimer’s disease (AD) or mild cognitive impairment (MCI). Abnormalities were detected in the subjects with AD and MCI, and theirALPS index and FW-WM values were significantly associated with CSF Aβ levels and FDG PET uptake, as well as with multiple cognitive scores, thus suggesting that a glymphatic system dysfunction could be associated with Aβ deposition and cognitive impairments.
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