Abstract #3589

Non-invasive MRI measures of glymphatic system activity associated with CSF-Aβ and FDG-PET uptakes in Alzheimer’s disease

Koji Kamagata¹, Christina Andica¹, Kaito Takabayashi¹, Yuya Saito¹, Toshiaki Taoka², Hayato Nozaki¹, Junko Kikuta¹, Shohei Fujita¹, Kouhei Kamiya³, Akihiko Wada¹, Toshiaki Akashi¹, Masaaki Hori³, Shinji Naganawa², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, Nagoya University, Aichi, Japan, ³Department of Radiology, Toho University, Tokyo, Japan

Synopsis

We assessed the non-invasive MRI measurements, such as the diffusivity along the perivascular space (PVS) represented by ALPS index, PVS volume, and fractional volume of free water in the white matter (FW-WM), in cognitively normal subjects and subjects with Alzheimer’s disease (AD) or mild cognitive impairment (MCI). Abnormalities were detected in the subjects with AD and MCI, and theirALPS index and FW-WM values were significantly associated with CSF Aβ levels and FDG PET uptake, as well as with multiple cognitive scores, thus suggesting that a glymphatic system dysfunction could be associated with Aβ deposition and cognitive impairments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.