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Abstract #3590

The structural and functional change of glymphatic system in children with ADHD

Yingqian Chen1, Shu Su1, Yan Dai1, Long Qian2, Miaomiao Wang3, and Zhiyun Yang1
1First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2GE Healthcare, Beijing, China, 3the first affliated hospital of Xi'an Jiaotong University, Xi'an, China


The newly found structure – glymphatic system, may offer a new point for exploring the pathogenesis of attention deficit hyperactivity disorder (ADHD),. Our study investigated the change of glymphatic system in the treatment-naïve ADHD children by quantitatively measuring the VRS volume and using DTI-ALPS method. As the results showed, ADHD children have enlarged VRS, and the diffusivities along the VRS and ALPS-index were significantly lower in children with ADHD than in TD subjects, suggesting the impaired glymphatic drainage. Our study suggested that the glymphatic system alternation may play a role in the pathogenesis of ADHD and deserves further investigation.

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