The newly found structure – glymphatic system, may offer a new point for exploring the pathogenesis of attention deficit hyperactivity disorder (ADHD),. Our study investigated the change of glymphatic system in the treatment-naïve ADHD children by quantitatively measuring the VRS volume and using DTI-ALPS method. As the results showed, ADHD children have enlarged VRS, and the diffusivities along the VRS and ALPS-index were significantly lower in children with ADHD than in TD subjects, suggesting the impaired glymphatic drainage. Our study suggested that the glymphatic system alternation may play a role in the pathogenesis of ADHD and deserves further investigation.
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