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Abstract #3593

Postnatal experience promotes the thickening but not myelination of the neonatal ventral visual cortex

Mingyang Li1, Tingting Liu1, Xinyi Xu1, Qingqing Wen1, Zhiyong Zhao1, Yi Zhang1, Yi-Cheng Hsu2, Yi Sun2, and Dan Wu1
1College of Biomedical Engineering & Instrument Science, Zhejiang University, Zhejiang, China, 2MR Collaboration, Siemens Healthineers Ltd, Shanghai, China


Postnatal experience is important for the development of the visual cortex in animal newborns, but its influence in human infants remains unclear. We collected a dataset from the developing human connectome project, including multi-modal MRI of 783 newborns. We found the cortical thickness (CT) and myelination of ventral visual cortex were significantly increased between 37 and 45 weeks of postmenstrual menstrual age (PMA). Interestingly, the CT but not myelination showed significant correlation with postnatal experience in both the V1 and higher-level visual cortex. Our result suggested that experience plays an important role in early cortical thickening

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