Abstract #3594

Longitudinal Development of Regional Cerebellar Volumes from Birth to 27 Months of Age

Ya Wang^1,2, Liangjun Chen², Yue Sun², Tengfei Li², Zhengwang Wu², Wenhua Huang¹, Weili Lin², Li Wang², and Gang Li²

¹National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, ²Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Early cerebellar development in infant brains is very dynamic and highly related to normal cognitive functions and neurodevelopmental disorders, but remains largely unexplored, due to the lack of densely-sampled longitudinal data of early ages. Herein, we unprecedently explored the dynamic developmental trajectories of the volumes in 27 cerebellar lobules based on 511 high-resolution longitudinal structural MRI scans from 235 healthy infants from the Baby Connectome Project (BCP) densely covering the age ranging from birth to 27 months. The trajectories of the cerebellar structures reveal lobule-specific nonlinear developmental patterns and are sexually dimorphic starting from different ages.

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