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Abstract #3597

PM2.5 exposure induces structural and functional changes in the mouse brain

Xiaoyang Han1, Yuting Zhai1, and Xiao-Yong Zhang1
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China


We investigated the structural and functional changes induced by exposure in PM2.5 in the mouse model using MRI at 11.7T. We compared the gray matter volume ratio (GMR) of major brain regions between mice exposed to concentrated PM2.5 (PM) and mice exposed to filtered air (FA) after 30-day and 90-day exposure. Our results demonstrate that exposure to PM2.5 for 90 days may induce brain structural and functional changes.

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