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Abstract #3602

Transcriptomic Signatures Associated With Gray Matter Volume Changes In Patients With Functional Constipation

Wangli Cai1, Guangyu Tang1, Jilei Zhang2, Ruiling Zhang1, and Lidi Wan1
1Shanghai Tenth People’s Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China


Functional constipation (FCon) is a common functional gastrointestinal disorder, with a considerable proportion of patients has anxiety and depression. Neuroimaging studies have shown that the functional/structural abnormalities across patients. We aimed to better understand the relationships between cortical atrophy and clinical observations in FCon, and its relationship with the underlying molecular mechanisms. Based on the densely sampled gene expression data from the Allen Human Brain Atlas, we conducted the transcription-neuroimaging association analysis and found genes associated with the central nervous system and the bowel to understand the molecular functions of brain regions that are vulnerable to cortical atrophy in FCon.

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