Radiation-induced structural network alterations in patients with nasopharyngeal carcinoma: a longitudinal study
Xinyuan Zhang1, Xiaofei Lv2, Pu Xu1, Yuhao Lin1, Long Qian3, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China, 3MR Research, GE Healthcare, Beijing, China
We conducted a longitudinal study to explore the radiation-induced alterations of structural brain network for nasopharyngeal carcinoma (NPC) patients using diffusion tensor imaging (DTI) technique and graph theory. The dose-dependent effect was also investigated using Spearman's Rank Correlation Coefficient. The structural brain connectivity was found to be altered at both 0~3 (acute) and 6 months (early-delayed) after radiotherapy (RT) and showed a tendency of recovery at 12 months (late-delayed) after RT. Also, the change of nodal properties were related to the temporal dose. These findings provide new insights into the pathophysiological mechanism of radiation-induced brain injuries.
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