Abstract #3605

Dysfunctional interaction between the dorsal attention network and the default mode network in Patients with Type 2 Diabetes Mellitus

Yumeng Lei¹, Dongsheng Zhang¹, Fei Qi¹, Jie Gao¹, Min Tang¹, Kai Ai², Xuejiao Yan¹, Xiaoyan Lei¹, Zhirong Shao³, Yu Su¹, and Xiaoling Zhang¹

¹Department of MRI, Shaanxi Provincial People’s Hospital, Xi’an, China, ²Philips Healthcare, Xi'an, China, ³Xi'an Medical University, Xi’an, China

Synopsis

To investigate the specific neural substrate of type 2 diabetes mellitus (T2DM) -related cognitive impairment, independent component analysis (ICA) and functional network connection analysis (FNC) methods were applied to resting-state fMRI images from 44 patients with T2DM and 47 healthy controls (HCs). This study found the inherent neural mechanism between the dorsal attention network (DAN) and default mode network (DMN) was eliminated, and these abnormal changes were correlated with the scores of multiple neuropsychological assessments (P < 0.05), indicated that the abnormal changes of the DAN-DMN may be the neural basis of T2DM-related cognitive deficits.

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