Meeting Banner
Abstract #3605

Dysfunctional interaction between the dorsal attention network and the default mode network in Patients with Type 2 Diabetes Mellitus

Yumeng Lei1, Dongsheng Zhang1, Fei Qi1, Jie Gao1, Min Tang1, Kai Ai2, Xuejiao Yan1, Xiaoyan Lei1, Zhirong Shao3, Yu Su1, and Xiaoling Zhang1
1Department of MRI, Shaanxi Provincial People’s Hospital, Xi’an, China, 2Philips Healthcare, Xi'an, China, 3Xi'an Medical University, Xi’an, China


To investigate the specific neural substrate of type 2 diabetes mellitus (T2DM) -related cognitive impairment, independent component analysis (ICA) and functional network connection analysis (FNC) methods were applied to resting-state fMRI images from 44 patients with T2DM and 47 healthy controls (HCs). This study found the inherent neural mechanism between the dorsal attention network (DAN) and default mode network (DMN) was eliminated, and these abnormal changes were correlated with the scores of multiple neuropsychological assessments (P < 0.05), indicated that the abnormal changes of the DAN-DMN may be the neural basis of T2DM-related cognitive deficits.

This abstract and the presentation materials are available to members only; a login is required.

Join Here