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Abstract #3608

Altered neurovascular coupling in drug-naïve attention-deficit/hyperactivity disorder: Evidence from a comprehensive fMRI analysis

shu su1, Yingqian Chen 1, Long Qian 2, Yan Dai 1, Zi Yan1, Liping Lin1, Mengsha Zou1, Qin Zhou1, Meina Liu1, Hongyu Zhang1, and Zhiyun Yang1
1First Affiliated Hospital, Sun Yat-sen University, guangzhou, China, 2MR Research, GE Healthcare, guangzhou, China


As the most common childhood-onset neurodevelopmental disorder, the pathogenesis of attention-deficit/ hyperactivity disorder (ADHD) is still unclear. Non-invasive neuroimaging methods open new avenues to characterize developmental changes in the human brain. Neurovascular coupling (NVC) reflects the close relationship between neuronal activity and cerebral blood flow (CBF), which provides a new mechanistic insight into developmental brain alteration. We aim to investigate the potential NVC alteration in ADHD children.

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