Abstract #3609

Disrupted topological organization in cerebral small vessel disease: A resting-state functional brain networks and graph theory study

Haotian Xin¹, Hongwei Wen^2,3, Mengmeng Feng¹, Lingfei Guo⁴, and Changhu Liang⁴

¹Cheeloo College of Medicine, Shandong University, Jinan, China, ²Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, China, ³School of Psychology, Southwest University, Chongqing, China, ⁴Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Synopsis

We aim to investigate functional topological brain networks changes in cerebral small vessel disease (CSVD) patients with and without cerebral microbleeds (CMBs). We divided the subjects into three subgroups: CSVD with CMBs (CSVD-c), CSVD without CMBs (CSVD-n) and control. Then, we analyzed topological disruptions between groups using graph theory and related these alterations to clinical parameters. CSVD-c showed significantly altered global, nodal topological properties and disrupted distribution of hub regions, involving the default mode network (DMN), attention, sensorimotor and visual functional areas. These findings extended our understanding of neurobiological mechanisms of CSVD.

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