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Abstract #3610

Static and temporal dynamic changes of intrinsic brain activity in adolescents and adult OCD patients

Xu yin huan1, Zheng rui ping1, Wei ya rui1, Han shao qiang1, and Zhang yan1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China


This study used a novel statistical analysis-2x2 interaction effect to differentiate OCD patients from healthy controls in both adolescents and adults. We analyzed a classical index-low frequency fluctuation amplitude(ALFF) and drew a convincing conclusion that some regions had a correlation with people in different age and symptoms in OCD patients. Originally, we proposed a novel strategy of dALFF which allows estimating dynamics of intrinsic brain activity with patients. Compared to static indexes, dynamic indexes might be used as a powerful supplement differentiating patients from different age, helping us obtain a more comprehensive understanding of neural activity.

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