The relationship among cerebral blood flow (CBF), functional connectivity (FC), and suicidal ideation (SI) in MDD patients has been elusive. 175 participants including 47 MDD without SI (MDDNSI), 59 MDD with SI (MDDSI), and 69 controls (HC) underwent ASL, resting-state fMRI scans, and completed neuropsychological tests. Results showed that CBF was increased in MDDSI patients in the bilateral precuneus. MDDSI patients exhibited enhanced FC in the prefrontal-limbic system and decreased FC in the right precentral gyrus relative to MDDNSI patients. Mediation analyses identified that the FC could mediate the association between CBF and behavioral performance in subgroups.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords