Abstract #3612

Altered resting-state cerebral blood flow and functional connectivity mediate suicidal ideation in major depressive disorder

Dandan Fan¹, Cancan He¹, Xinyi Liu¹, Feifei Zang¹, Yao Zhu¹, and Chunming Xie^1,2,3

¹Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, ²Neuropsychiatric Institute, Affiliated ZhongDa Hospital, Southeast University, Nanjing, China, ³The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China

Synopsis

The relationship among cerebral blood flow (CBF), functional connectivity (FC), and suicidal ideation (SI) in MDD patients has been elusive. 175 participants including 47 MDD without SI (MDDNSI), 59 MDD with SI (MDDSI), and 69 controls (HC) underwent ASL, resting-state fMRI scans, and completed neuropsychological tests. Results showed that CBF was increased in MDDSI patients in the bilateral precuneus. MDDSI patients exhibited enhanced FC in the prefrontal-limbic system and decreased FC in the right precentral gyrus relative to MDDNSI patients. Mediation analyses identified that the FC could mediate the association between CBF and behavioral performance in subgroups.

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