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Abstract #3613

Dynamic Alterations in SpontaneousNeural Activity in First-Episode, Drug-Naive Patients with Major Depressive Disorder.

Yingying Wang1, Jing Liu1, Hailong Li1, Hui Qiu1, Yingxue Gao1, Zilin Zhou1, Kaili Liang1, Weijie Bao1, Lianqing Zhang1, Qiyong Gong1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China


We collected resting-state fMRI data from 115 patients with major depressive disorder (MDD) and 127 normal controls (NC). The dynamic amplitude of low-frequency fluctuations (dALFF) and dynamic regional homogeneity (dReHo) in 115 MDD patients and 127 NC were compared. Correlation analyses between dALFF and dReHo in brain regions showing significant intergroup differences and clinical scores were calculated in MDD patients. We found aberrant dALFF and dReHo in MDD patients and their significant correlations with clinical scores, suggesting the pattern of intrinsic brain activity variability might be potential tools to assess MDD patients’ severity of illness.

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