Abstract #3613

Dynamic Alterations in SpontaneousNeural Activity in First-Episode, Drug-Naive Patients with Major Depressive Disorder.

Yingying Wang¹, Jing Liu¹, Hailong Li¹, Hui Qiu¹, Yingxue Gao¹, Zilin Zhou¹, Kaili Liang¹, Weijie Bao¹, Lianqing Zhang¹, Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Synopsis

We collected resting-state fMRI data from 115 patients with major depressive disorder (MDD) and 127 normal controls (NC). The dynamic amplitude of low-frequency fluctuations (dALFF) and dynamic regional homogeneity (dReHo) in 115 MDD patients and 127 NC were compared. Correlation analyses between dALFF and dReHo in brain regions showing significant intergroup differences and clinical scores were calculated in MDD patients. We found aberrant dALFF and dReHo in MDD patients and their significant correlations with clinical scores, suggesting the pattern of intrinsic brain activity variability might be potential tools to assess MDD patients’ severity of illness.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.