We collected resting-state fMRI data from 115 patients with major depressive disorder (MDD) and 127 normal controls (NC). The dynamic amplitude of low-frequency fluctuations (dALFF) and dynamic regional homogeneity (dReHo) in 115 MDD patients and 127 NC were compared. Correlation analyses between dALFF and dReHo in brain regions showing significant intergroup differences and clinical scores were calculated in MDD patients. We found aberrant dALFF and dReHo in MDD patients and their significant correlations with clinical scores, suggesting the pattern of intrinsic brain activity variability might be potential tools to assess MDD patients’ severity of illness.
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