Most previous studies took DMN as a whole and measured its FC abnormalities on a network level while recently, researchers revealed DMN has three subsystems (core, dMPFC and MTL subsystem). Few studies had explored FC on subsystem levels in first-episode drug-naïve (FEDN) MDD patients. We used seed-based whole-brain functional connectivity analysis in a relatively large sample of FEDN MDD patients, we found hyper-connectivity between DMN three subsystems and frontoparietal network as well as cerebellum network, and hypo-connectivity between dMPFC subsystem and dorsal attention network. These findings might provide a more comprehensive understanding for DMN FC changes in MDD.
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