Meeting Banner
Abstract #3614

Abnormal functional connectivity of default mode network subsystems in first-episode drug-naïve major depressive disorder

Hui Qiu1, Hailong Li1, Yingxue Gao1, Lingxiao Cao1, Jing Liu1, Weijie Bao1, Yingying Wang1, Zilin Zhou1, Suming Zhang1, Mengyue Tang1, Lianqing Zhang1, Lu Lu1, Xiaoqi Huang1, and Qiyong Gong1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China


Most previous studies took DMN as a whole and measured its FC abnormalities on a network level while recently, researchers revealed DMN has three subsystems (core, dMPFC and MTL subsystem). Few studies had explored FC on subsystem levels in first-episode drug-naïve (FEDN) MDD patients. We used seed-based whole-brain functional connectivity analysis in a relatively large sample of FEDN MDD patients, we found hyper-connectivity between DMN three subsystems and frontoparietal network as well as cerebellum network, and hypo-connectivity between dMPFC subsystem and dorsal attention network. These findings might provide a more comprehensive understanding for DMN FC changes in MDD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here