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Abstract #3615

Brain mapping of the temporal interference stimulation wth functional MRI

Zonghao Xin1, Yoshifumi Abe2, Akihiro Kuwahata3, Kenji F. Tanaka2, and Masaki Sekino1
1Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan, 2Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan, 3Department of Electrical Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan


Temporal interference stimulation (TIS) is a novel, non-invasive deep brain stimulation (DBS) methodology thatutilizes multiple external electric fields with amplitude modulation (AM) to stimulate deep brain regions without affectingthe superficial cortical areas. However, the clinical application of TIS is inhibited by its unproved response of the brain to the modulated stimulation. In this study, we investigated the instantaneous brain response to TIS using fMRI technique in rodents. The results demonstrated the compatibility of TIS with fMRI, as well as the feasibility of stimulating subcortical encephalic regions non-invasively and focally.

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