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Abstract #3617

How does midazolam affect resting-state networks in common marmosets? An investigation using a 9.4 T magnetic resonance imaging system.

Kanako Muta1,2, Junichi Hata1,2,3,4, Yawara Haga1,3, Daisuke Yoshimaru2, Kei Hagiya3, Takaaki Kaneko3, Takako Miyabe-Nishiwaki5, Yuji Komaki6, Fumiko Seki6, Hirotaka James Okano2, and Hideyuki Okano3,4
1Tokyo Metropolitan University, Tokyo, Japan, 2The Jikei University School of Medicine, Tokyo, Japan, 3RIKEN Center for Brain Science, Saitama, Japan, 4Keio University, Tokyo, Japan, 5Kyoto University, Aichi, Japan, 6Central Institute for Experimental Animals, Kanagawa, Japan


The purpose of this study is to evaluate the effects of midazolam on resting-state networks in common marmosets. Functional data were collected using a 9.4 T MRI system in the sedative condition with midazolam, the awake condition as a positive control, and the anesthetic condition with isoflurane as a negative control. Independent component analysis and functional connectivity analysis were performed. These results were apparently altered by isoflurane from awake condition, but not largely by midazolam. These results in midazolam were different from a previous report in humans and it may cause different effects of midazolam in human and nonhuman primates.

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