Abstract #3617

How does midazolam affect resting-state networks in common marmosets? An investigation using a 9.4 T magnetic resonance imaging system.

Kanako Muta^1,2, Junichi Hata^1,2,3,4, Yawara Haga^1,3, Daisuke Yoshimaru², Kei Hagiya³, Takaaki Kaneko³, Takako Miyabe-Nishiwaki⁵, Yuji Komaki⁶, Fumiko Seki⁶, Hirotaka James Okano², and Hideyuki Okano^3,4

¹Tokyo Metropolitan University, Tokyo, Japan, ²The Jikei University School of Medicine, Tokyo, Japan, ³RIKEN Center for Brain Science, Saitama, Japan, ⁴Keio University, Tokyo, Japan, ⁵Kyoto University, Aichi, Japan, ⁶Central Institute for Experimental Animals, Kanagawa, Japan

Synopsis

The purpose of this study is to evaluate the effects of midazolam on resting-state networks in common marmosets. Functional data were collected using a 9.4 T MRI system in the sedative condition with midazolam, the awake condition as a positive control, and the anesthetic condition with isoflurane as a negative control. Independent component analysis and functional connectivity analysis were performed. These results were apparently altered by isoflurane from awake condition, but not largely by midazolam. These results in midazolam were different from a previous report in humans and it may cause different effects of midazolam in human and nonhuman primates.

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