Abstract #3618

Are topographically segregated excitatory neurons in visual thalamus functionally diverse? An optogenetic fMRI study

Linshan Xie^1,2, Xunda Wang^1,2, Teng Ma^1,2,3, Pit Shan Chong⁴, Lee Wei Lim⁴, Peng Cao³, Pek-Lan Khong³, Ed X. Wu^1,2, and Alex T. L. Leong^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, ³Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, ⁴School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Synopsis

The dorsal lateral geniculate nucleus (dLGN) plays an essential role in visual processing. There are two types of topographically segregated excitatory neurons in dLGN with different outputs to visual cortex, suggesting functional differences when processing visual inputs at the subcortical thalamic level. However, their long-range functional pathways have yet to be reported. Here, we employed optogenetics in combination with fMRI to precisely target the two subdivisions of dLGN and examine whether these two types of neurons are truly functionally diverse at the systems level to facilitate various known complex visual processing functions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.