Are topographically segregated excitatory neurons in visual thalamus functionally diverse? An optogenetic fMRI study
Linshan Xie1,2, Xunda Wang1,2, Teng Ma1,2,3, Pit Shan Chong4, Lee Wei Lim4, Peng Cao3, Pek-Lan Khong3, Ed X. Wu1,2, and Alex T. L. Leong1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
The dorsal lateral geniculate nucleus (dLGN) plays an essential role in visual processing. There are two types of topographically segregated excitatory neurons in dLGN with different outputs to visual cortex, suggesting functional differences when processing visual inputs at the subcortical thalamic level. However, their long-range functional pathways have yet to be reported. Here, we employed optogenetics in combination with fMRI to precisely target the two subdivisions of dLGN and examine whether these two types of neurons are truly functionally diverse at the systems level to facilitate various known complex visual processing functions.
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