Preoperative evaluation of the consistency of pituitary macroadenomas plays a significant role in the determination of the surgical strategy. However, previous studies concerning the assessment of tumor consistency of macroadenomas were controversial1-4. Diffusion-relaxation correlation spectrum imaging (DR-CSI), which provides a correlation spectrum of both water molecular diffusion and T2 relaxation, could be used to resolve the information of tissue compositions, compartments, and heterogeneity at a sub-voxel level. The purpose of our study is to evaluate the utility of DR-CSI in assessing the consistency of pituitary macroadenomas.
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