Abstract #3623

The shared and disorder-specific temporal dynamics in degree centrality for patients with obsessive-compulsive disorder and schizophrenia

Yaxuan Wang¹, Lekai Luo¹, Qian Li¹, Wanfang You¹, Yuxia Wang¹, Qian Zhang¹, Su Lui¹, Qiyong Gong¹, and Fei Li¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China., Chengdu, China

Synopsis

Temporal dynamics in degree centrality (DC) were measured to detect alterations of dynamic topological organization in patients with obsessive-compulsive disorder (OCD) and schizophrenia (SZ). We found both patients with OCD and SZ showed decreased occurrence of a state manifested as the highest centrality in sensory systems. Moreover, we observed common and specific alteration of temporal variability of DC in some brain regions, which correlated with symptom severity of patients, respectively.

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