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Abstract #3623

The shared and disorder-specific temporal dynamics in degree centrality for patients with obsessive-compulsive disorder and schizophrenia

Yaxuan Wang1, Lekai Luo1, Qian Li1, Wanfang You1, Yuxia Wang1, Qian Zhang1, Su Lui1, Qiyong Gong1, and Fei Li1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, P.R. China., Chengdu, China


Temporal dynamics in degree centrality (DC) were measured to detect alterations of dynamic topological organization in patients with obsessive-compulsive disorder (OCD) and schizophrenia (SZ). We found both patients with OCD and SZ showed decreased occurrence of a state manifested as the highest centrality in sensory systems. Moreover, we observed common and specific alteration of temporal variability of DC in some brain regions, which correlated with symptom severity of patients, respectively.

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