This work sought to identify a new non-invasive means to differentiate high-grade gliomas (HGGs) from solitary brain metastases (SBMs). It was concluded that the T1native, T2native, PDnative, and ΔT1ratio values were measured in peritumoral brain zone from synthetic MRI can be used as quantitative imaging biomarkers for distinguishing between HGGs and SBMs. The ΔT1ratio values have higher discrimination abilities compared with other parameters, which worth further study.
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