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Abstract #3625

Advanced diffusion-weighted imaging for differentiating between glioblastoma and primary central nervous system lymphoma

Kiyohisa Kamimura1, Masanori Nakajo1, Bohara Manisha1, Yoshihiko Fukukura1, Hiroyuki Uchida2, Takashi Iwanaga3, Thorsten Feiweier4, Hiroshi Imai5, and Takashi Yoshiura1
1Radiology, Kagoshima University, Kagoshima, Japan, 2Neurosurgery, Kagoshima University, Kagoshima, Japan, 3Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Siemens Healthcare K.K., Tokyo, Japan

Synopsis

To determine whether time-dependent DWI parameters and microscopic diffusion anisotropy (μFA) are useful for differentiating between glioblastoma and primary central nervous system lymphoma (PCNSL), 51 patients with glioblastoma and 13 with PCNSL were examined. In addition to ADC at two different diffusion times, ADC difference (ΔADC) and ADC change ratio (rcADC) were significantly different between the two tumor types, while no difference was shown for μFA. rcADC showed the best diagnostic performance followed by ΔADC.

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Keywords