Abstract #3625

Advanced diffusion-weighted imaging for differentiating between glioblastoma and primary central nervous system lymphoma

Kiyohisa Kamimura¹, Masanori Nakajo¹, Bohara Manisha¹, Yoshihiko Fukukura¹, Hiroyuki Uchida², Takashi Iwanaga³, Thorsten Feiweier⁴, Hiroshi Imai⁵, and Takashi Yoshiura¹

¹Radiology, Kagoshima University, Kagoshima, Japan, ²Neurosurgery, Kagoshima University, Kagoshima, Japan, ³Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Siemens Healthcare K.K., Tokyo, Japan

Synopsis

To determine whether time-dependent DWI parameters and microscopic diffusion anisotropy (μFA) are useful for differentiating between glioblastoma and primary central nervous system lymphoma (PCNSL), 51 patients with glioblastoma and 13 with PCNSL were examined. In addition to ADC at two different diffusion times, ADC difference (ΔADC) and ADC change ratio (rcADC) were significantly different between the two tumor types, while no difference was shown for μFA. rcADC showed the best diagnostic performance followed by ΔADC.

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