Premature infants with low-grade intraventricular hemorrhage (IVH) are accompanied by neurodevelopmental abnormalities. Synthetic MRI is an emerging technology that can provide brain volume quantification. Diffusion kurtosis imaging (DKI) can be sensitive to assess brain microstructure changes. Smaller myelin volume, brain parenchymal fraction, lower radial kurtosis value in cerebellum were associated with lower neonatal behavioral neurological assessment. DKI and Synthetic MRI are able to quantitatively evaluate the abnormality of the brain development in preterm infants with low-grade IVH.