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Abstract #3634

Brain structure and volume reveal neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage

Chunxiang Zhang1, Xin Zhao1, Jinxia Guo2, Kaiyu Wang2, Meiying Cheng1, Honglei Shang1, Xueyuan Wang1, Desheng Xuan1, Lingjie Zhang1, and Xiaoan Zhang1
1Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare, MR Research China, Beijing, China


Premature infants with low-grade intraventricular hemorrhage (IVH) are accompanied by neurodevelopmental abnormalities. Synthetic MRI is an emerging technology that can provide brain volume quantification. Diffusion kurtosis imaging (DKI) can be sensitive to assess brain microstructure changes. Smaller myelin volume, brain parenchymal fraction, lower radial kurtosis value in cerebellum were associated with lower neonatal behavioral neurological assessment. DKI and Synthetic MRI are able to quantitatively evaluate the abnormality of the brain development in preterm infants with low-grade IVH.

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