Abstract #3634

Brain structure and volume reveal neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage

Chunxiang Zhang¹, Xin Zhao¹, Jinxia Guo², Kaiyu Wang², Meiying Cheng¹, Honglei Shang¹, Xueyuan Wang¹, Desheng Xuan¹, Lingjie Zhang¹, and Xiaoan Zhang¹

¹Department of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²GE Healthcare, MR Research China, Beijing, China

Synopsis

Premature infants with low-grade intraventricular hemorrhage (IVH) are accompanied by neurodevelopmental abnormalities. Synthetic MRI is an emerging technology that can provide brain volume quantification. Diffusion kurtosis imaging (DKI) can be sensitive to assess brain microstructure changes. Smaller myelin volume, brain parenchymal fraction, lower radial kurtosis value in cerebellum were associated with lower neonatal behavioral neurological assessment. DKI and Synthetic MRI are able to quantitatively evaluate the abnormality of the brain development in preterm infants with low-grade IVH.

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