Abstract #3643

Altered neurochemical cerebral metabolism in patients with gluten ataxia: A pilot in-vivo proton MRS study

Uma Sharma¹, Vishwa Rawat¹, Prasenjit Das², Achal Kumar Srivastava³, and Govind Makharia⁴

¹Department of NMR, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ²Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ³Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ⁴Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Synopsis

Present study evaluated the neurochemical profile of vermis and right cerebellum of GA patients using 1H MRS. The concentration of N-acetyl aspartate (NAA), glycerophosphocholine (GPC)+phosphocholine (PC), creatine (Cr) + phosphocreatine (PCr) and glutamine (Gln)+glutamate (Glu) were significantly lower in the right cerebellum of patients with GA compared to HC. The concentration of NAA, Cr and Glu were significantly lower in vermis region of patients with GA compared to HC indicating altered cerebral metabolism in GA patients that would have contributed to cerebral damage. The metabolites NAA, GPC+PC, Glu+Gln may have the potential to serve as early indicators of neuronal damage.

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