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Abstract #3645

Decreased brain GABA levels in patients with migraine without aura: an exploratory 1H-MRS study

Xiaojuan Wu1, Shuting Han1, Yang Yang1, Hui Dai1, Peng Wu2, Hongru Zhao3, and Yonggang Li1
1Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China, 2Philips Healthcare, Shanghai, China, 3Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China


Increasing neurophysiological studies had revealed that regional excitation-inhibition imbalance in brain played a key role in the pathogenesis of migraine. This study explored the alterations in GABA and Glx levels in the anterior cingulate gyrus (ACC) and medial prefrontal lobe (mPFC) of patients with migraine without aura (MWoA) using MEGA-PRESS at 3 Tesla. Compared with healthy controls, the GABA+ levels in the ACC and mPFC of patients were lower and correlated with attack frequency, and Glx levels had no difference, suggesting a relationship of the abnormalities of GABAergic system in the ACC and mPFC with the pathophysiological mechanism of MWoA.

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