Abstract #3645

Decreased brain GABA levels in patients with migraine without aura: an exploratory 1H-MRS study

Xiaojuan Wu¹, Shuting Han¹, Yang Yang¹, Hui Dai¹, Peng Wu², Hongru Zhao³, and Yonggang Li¹

¹Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China, ²Philips Healthcare, Shanghai, China, ³Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China

Synopsis

Increasing neurophysiological studies had revealed that regional excitation-inhibition imbalance in brain played a key role in the pathogenesis of migraine. This study explored the alterations in GABA and Glx levels in the anterior cingulate gyrus (ACC) and medial prefrontal lobe (mPFC) of patients with migraine without aura (MWoA) using MEGA-PRESS at 3 Tesla. Compared with healthy controls, the GABA+ levels in the ACC and mPFC of patients were lower and correlated with attack frequency, and Glx levels had no difference, suggesting a relationship of the abnormalities of GABAergic system in the ACC and mPFC with the pathophysiological mechanism of MWoA.

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