Abstract #3646

Neuronal metabolic biomarkers in cerebellum of Spinocerebellar ataxia type 2 and 12 patients

Pankaj Pankaj¹, S Senthil Kumaran¹, Achal Kumar Srivastava², and Ramesh Kumar Agrawal³

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ³School of Computer & Systems Sciences, Jawaharlal Nehru University, New Delhi, India

Synopsis

Spinocerebellar Ataxia (SCA) is a genetic and hereditary disorder that leads to severe disability in balance, speech, posture, etc. SCA2 and SCA12 are two sub-types, which have different CAG repeat expansion on chromosome with different pathologies. In vivo MR spectroscopy was acquired using single voxel Point Resolved Spectroscopy Sequence (PRESS) in the left cerebellum. SCA2 showed a decrease in NAA and Cho and increased mI concentration as compared to controls and an increase in mI values as compared to that in SCA12, which may be attributed to the motor and cognitive dysfunctions in SCA, reflecting more atrophy in SCA2.

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