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Abstract #3647

Comparative analysis of diffusion-weighted image analysis along the perivascular space (DWI-ALPS) for evaluating interstitial fluid status

Toshiaki Taoka1, Rintaro Ito1, Rei Nakamichi2, Toshiki Nakane2, Kazushige Ichikawa3, Mayuko Sakai4, and Shinji Naganawa2
1Department of Innovative Biomedical Visualization (iBMV), Nagoya University, Nagoya, Japan, 2Department of Radiology, Nagoya University, Nagoya, Japan, 3Devision of Radiology, Nagoya University Hospital, Nagoya, Japan, 4Canon Medical Systems Corporation, Otawara, Japan


The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method has been developed to evaluate glymphatic function. In order to evaluate wider clinical cases, we developed a diffusion weighted image ALPS (DWI-ALPS) technique. The ALPS-index was retrospectively calculated by clinical DWI of normal subjects and those with pathologies. In normal subjects, the ALPS-index was highest in those in their forties and lowest in those in their seventies. Patients with Alzheimer’s disease and subdural hematoma showed a lower ALPS-index than age-matched normal subjects. The DWI-ALPS method seems to be feasible for evaluation of glymphatic function in the clinical practice.

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