Abstract #3647

Comparative analysis of diffusion-weighted image analysis along the perivascular space (DWI-ALPS) for evaluating interstitial fluid status

Toshiaki Taoka¹, Rintaro Ito¹, Rei Nakamichi², Toshiki Nakane², Kazushige Ichikawa³, Mayuko Sakai⁴, and Shinji Naganawa²

¹Department of Innovative Biomedical Visualization (iBMV), Nagoya University, Nagoya, Japan, ²Department of Radiology, Nagoya University, Nagoya, Japan, ³Devision of Radiology, Nagoya University Hospital, Nagoya, Japan, ⁴Canon Medical Systems Corporation, Otawara, Japan

Synopsis

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method has been developed to evaluate glymphatic function. In order to evaluate wider clinical cases, we developed a diffusion weighted image ALPS (DWI-ALPS) technique. The ALPS-index was retrospectively calculated by clinical DWI of normal subjects and those with pathologies. In normal subjects, the ALPS-index was highest in those in their forties and lowest in those in their seventies. Patients with Alzheimer’s disease and subdural hematoma showed a lower ALPS-index than age-matched normal subjects. The DWI-ALPS method seems to be feasible for evaluation of glymphatic function in the clinical practice.

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