Abstract #3648

The Role of Electric Properties Tomography in Biochemical Analysis of the Cerebrospinal Fluid and Parameter Optimization for Improved Accuracy

Khin Khin Tha¹, Ulrich Katscher², Hiroyuki Hamaguchi³, Xinnan Li³, Tomohiro Kawasaki⁴, Shigeru Yamaguchi⁵, Ichiro Yabe⁵, and Hideki Hyodoh⁵

¹Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan, ²Philips Research, Hamburg, Germany, ³Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ⁴Hokkaido University Hospital, Sapporo, Japan, ⁵Hokkaido University Faculty of Medicine, Sapporo, Japan

Synopsis

This study was aimed to evaluate if electrical conductivity (σ) by electric properties tomography (EPT) could detect variations in the cerebrospinal fluid (CSF) biochemical composition and if optimization of scan and analysis parameters improved the accuracy of in vivo σ measurements. σ values varied among patients and CSF samples with varying CSF biochemical composition, and showed significant correlation with CSF albumin concentration and total cell count. σ may be sensitive to CSF abnormalities. Optimization of scan and analysis parameters is important for the accuracy of in vivo σ measurements.

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