The Role of Electric Properties Tomography in Biochemical Analysis of the Cerebrospinal Fluid and Parameter Optimization for Improved Accuracy
Khin Khin Tha1, Ulrich Katscher2, Hiroyuki Hamaguchi3, Xinnan Li3, Tomohiro Kawasaki4, Shigeru Yamaguchi5, Ichiro Yabe5, and Hideki Hyodoh5
1Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan, 2Philips Research, Hamburg, Germany, 3Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 4Hokkaido University Hospital, Sapporo, Japan, 5Hokkaido University Faculty of Medicine, Sapporo, Japan
This study was aimed to evaluate if electrical conductivity (σ) by electric properties tomography (EPT) could detect variations in the cerebrospinal fluid (CSF) biochemical composition and if optimization of scan and analysis parameters improved the accuracy of in vivo σ measurements. σ values varied among patients and CSF samples with varying CSF biochemical composition, and showed significant correlation with CSF albumin concentration and total cell count. σ may be sensitive to CSF abnormalities. Optimization of scan and analysis parameters is important for the accuracy of in vivo σ measurements.
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