Abstract #3688

DPG-BUDA: Distortion-free diffusion-weighted renal MRI in small rodents

Qiang Liu^1,2,3, Yingjie Mei^1,2,3, Quan Tao^1,2,3, Qiqi Lu^1,2,3, Xinyuan Zhang^1,2,3, and Yanqiu Feng^1,2,3

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, ³Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence & Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China

Synopsis

We introduced blip-up/down acquisition (BUDA) strategy for interleaved 2-shot EPI to achieve motion robust, distortion-free rat renal diffusion-weighted imaging (DWI). Dual-polarity GRAPPA (DPG) method was implemented to correct Nyquist ghost artifact while simultaneously reconstructing the undersampled 2-shot data, then the field map was estimated from the opposing-distorted images. The field map was incorporated into a joint reconstruction with a structure low-rank constraint across the two shots to eliminate distortion and phase inconsistencies. DPG-BUDA permits high anatomical integrity while holding high scan efficiency for renal DWI in small rodents, it has the potential to benefit the characterization of the renal microstructure.

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