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Abstract #3688

DPG-BUDA: Distortion-free diffusion-weighted renal MRI in small rodents

Qiang Liu1,2,3, Yingjie Mei1,2,3, Quan Tao1,2,3, Qiqi Lu1,2,3, Xinyuan Zhang1,2,3, and Yanqiu Feng1,2,3
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, 3Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence & Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China


We introduced blip-up/down acquisition (BUDA) strategy for interleaved 2-shot EPI to achieve motion robust, distortion-free rat renal diffusion-weighted imaging (DWI). Dual-polarity GRAPPA (DPG) method was implemented to correct Nyquist ghost artifact while simultaneously reconstructing the undersampled 2-shot data, then the field map was estimated from the opposing-distorted images. The field map was incorporated into a joint reconstruction with a structure low-rank constraint across the two shots to eliminate distortion and phase inconsistencies. DPG-BUDA permits high anatomical integrity while holding high scan efficiency for renal DWI in small rodents, it has the potential to benefit the characterization of the renal microstructure.

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