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Abstract #3689

Synthetic MRI with quantitative mappings for identifying HER2-enriched breast cancers and differentiating them from other molecular subtypes

Weibo Gao1, Quanxin Yang1, and Xiaocheng Wei2
1Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, 2GE Healthcare, MR Research China, Beijing, China


In this study, we aim to investigate whether quantitative parameters of synthetic MRI can be used to differentiate among molecular subtypes and prognostic factors in patients with breast cancer. It was concluded that SD of PD-Pre was significantly different between HER2-enriched and non-HER2-enriched breast cancers, which displayed optimal performance than others. Quantitative T2-Pre, T2-Gd, SD of PD-Pre, and SD of PD-Gd were significantly different in the molecular subtypes and can further differentiate luminal breast cancers from non-luminal subtypes. T1-Pre, T2-Pre, and SD of PD-Gd were significantly different between triple negative (TN) and non-TN breast cancers.

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