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Abstract #3714

Spatiotemporal structural atlas of the fetal brain depicts cortical developmental patterns in a Chinese population 

Xinyi Xu1, Jiwei Sun1, Wen Shi1,2, Yao Shen1, Ruoke Zhao1, Wanrong Luo1, Cong Sun3, Ruike Chen1, Mingyang Li1, Yi-Cheng Hsu4, Yi Sun4, Yi Zhang1, Guangbin Wang3,5, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biodical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, HangZhou, China, 2Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Radiology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China, 4MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, 5Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China


We constructed a 4D spatiotemporal atlas of the normal fetal brain development from 23 to 38 gestational weeks in a Chinese population. We depicted the developmental trajectories of morphological indices of the cerebral cortex, which showed a characteristic regional variations and indicated the developmental order and rates in the different cortical parcels. The fetal brain atlas and fetal cerebral cortex trajectory offer a better understanding of fetal brain development and can be used as an analytic reference for clinicians in diagnostic or research settings.

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