Abstract #3720

Cortical development over the first 13 years of life after very preterm birth

Claire Kelly^1,2,3, Deanne K Thompson^2,3,4, Chris Adamson³, Gareth Ball^3,4, Thijs Dhollander³, Richard Beare³, Bonnie Alexander^3,5, Jeanie LY Cheong^2,6,7, Marc L Seal^3,4, Terrie E Inder⁸, Lex W Doyle^2,4,6,7, and Peter J Anderson^1,2

¹Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia, ²Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ³Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ⁴Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ⁵Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, ⁶The Royal Women's Hospital, Melbourne, Australia, ⁷Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, ⁸Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States

Synopsis

Longitudinal cortical development following very preterm (VP) birth has been infrequently studied. We undertook a unique longitudinal MRI study of 202 VP infants and 66 term-born infants from shortly after birth to age 13 years. Longitudinal changes in surface-based volume, area and thickness measurements for 62 cortical regions were modelled using generalised additive models. We reveal cortical alterations in the neonatal period and altered cortical development in the early years of life following VP birth. Cortical alterations persisted to age 13, with several regions of reduced volume and area, thickness reductions in temporal regions, and thickness increases in frontal regions.

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