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Abstract #3720

Cortical development over the first 13 years of life after very preterm birth

Claire Kelly1,2,3, Deanne K Thompson2,3,4, Chris Adamson3, Gareth Ball3,4, Thijs Dhollander3, Richard Beare3, Bonnie Alexander3,5, Jeanie LY Cheong2,6,7, Marc L Seal3,4, Terrie E Inder8, Lex W Doyle2,4,6,7, and Peter J Anderson1,2
1Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia, 2Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 3Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 4Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 5Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 6The Royal Women's Hospital, Melbourne, Australia, 7Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 8Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States


Longitudinal cortical development following very preterm (VP) birth has been infrequently studied. We undertook a unique longitudinal MRI study of 202 VP infants and 66 term-born infants from shortly after birth to age 13 years. Longitudinal changes in surface-based volume, area and thickness measurements for 62 cortical regions were modelled using generalised additive models. We reveal cortical alterations in the neonatal period and altered cortical development in the early years of life following VP birth. Cortical alterations persisted to age 13, with several regions of reduced volume and area, thickness reductions in temporal regions, and thickness increases in frontal regions.

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