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Abstract #3728

Whole-brain oxygen metabolism in adults with sickle-cell disease using susceptometry and T2-based method

Pei-Hsin Wu1, Felix W Wehrli2, and Seyed A Nabavizadeh2
1Department of Electrical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States


SvO2 and CMRO2 in patients with sickle cell anemia (SCA) were evaluated by MR susceptibility-based oximetry and compared with that derived from T2-based methods. The results show that (1) SvO2 trends lower and OEF tends to be higher in T2-based methods, (2) there is high correlation of CMRO2 between SBO and HbS model, (3) CMRO2 derived from SBO indicates tCBF was elevated to maintain oxygen delivery and oxygen metabolism in the brain given that CMRO2 is comparable with the healthy subjects reported previously. The preliminary results demonstrate the feasibility of OEF and CMRO2 estimation via SBO in subjects with SCA.

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