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Abstract #3729

Hemodynamics, brain volume and cortical development in fetuses with complex congenital heart disease

Cong Sun1, Xinyi Xu2, Jiaguang Song3, Yufan Chen1, Chao Zhang1, Yuhao Liao2, Wanrong Luo2, Jinxia Zhu4, Dan Wu2, and Guangbin Wang1,3
1Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, 2Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 4Siemens Healthineers Ltd, Beijing, China


Fetuses with complex congenital heart disease (CHD, n=23) and healthy gestational age-matched controls (n=25) were investigated. Hemodynamics were assessed by Doppler examinations. Fetal brain MR images were segmented to get global and regional morphological measurements. Results showed that fetuses with CHD have abnormally higher umbilical artery pulsation index and smaller global and regional brain volumes as early as 20-30 weeks; however, thickness, mean curvature, and sulcal depth of different brain lobes showed no statistical difference from the healthy controls. These results add to growing evidence of antenatal brain abnormalities of the CHD fetuses during the second and early third trimesters.

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