Abstract #3729

Hemodynamics, brain volume and cortical development in fetuses with complex congenital heart disease

Cong Sun¹, Xinyi Xu², Jiaguang Song³, Yufan Chen¹, Chao Zhang¹, Yuhao Liao², Wanrong Luo², Jinxia Zhu⁴, Dan Wu², and Guangbin Wang^1,3

¹Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, ²Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ³Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁴Siemens Healthineers Ltd, Beijing, China

Synopsis

Fetuses with complex congenital heart disease (CHD, n=23) and healthy gestational age-matched controls (n=25) were investigated. Hemodynamics were assessed by Doppler examinations. Fetal brain MR images were segmented to get global and regional morphological measurements. Results showed that fetuses with CHD have abnormally higher umbilical artery pulsation index and smaller global and regional brain volumes as early as 20-30 weeks; however, thickness, mean curvature, and sulcal depth of different brain lobes showed no statistical difference from the healthy controls. These results add to growing evidence of antenatal brain abnormalities of the CHD fetuses during the second and early third trimesters.

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