Regional brain ADC value changes in fetuses with complex congenital heart diseases in the second and early third trimesters
Cong Sun1, Jiaguang Song2, Yufan Chen1, Jinxia Zhu3, and Guangbin Wang1,4
1Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, 2Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 3Siemens Healthineers Ltd, Beijing, China, 4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, Jinan, China
We measured apparent diffusion coefficient (ADC) values in the brains of 64 normal fetuses at 20-40 gestational weeks and 23 fetuses with complex CHD during second and early third trimesters. We also compared ADC values between the fetuses with CHD and the 27 gestational age-matched normal controls using covariance analyses. Our results showed normal variations in ADC values for fetal brains during maturation in utero. Moreover, the ADC values in the CHD group were not significantly different than the GA-matched normal fetuses, indicating that myelin development was not delayed in the CHD fetuses during the second and early third trimesters.
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