Abstract #3730

Regional brain ADC value changes in fetuses with complex congenital heart diseases in the second and early third trimesters

Cong Sun¹, Jiaguang Song², Yufan Chen¹, Jinxia Zhu³, and Guangbin Wang^1,4

¹Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, ²Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ³Siemens Healthineers Ltd, Beijing, China, ⁴Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, Jinan, China

Synopsis

We measured apparent diffusion coefficient (ADC) values in the brains of 64 normal fetuses at 20-40 gestational weeks and 23 fetuses with complex CHD during second and early third trimesters. We also compared ADC values between the fetuses with CHD and the 27 gestational age-matched normal controls using covariance analyses. Our results showed normal variations in ADC values for fetal brains during maturation in utero. Moreover, the ADC values in the CHD group were not significantly different than the GA-matched normal fetuses, indicating that myelin development was not delayed in the CHD fetuses during the second and early third trimesters.

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