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Abstract #3746

How does Levodopa treatment in Parkinson’s disease impact perfusion: A MR pCASL Study

Hanyu Wei1,2, Le He1, Rui Li1, and Yu Ma3
1Tsinghua University, Beijing, China, 2Tsinghua University, Bejing, China, 3Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, China


Levodopa therapy of Parkinson’s disease(PD) was considered to have effects on dopamine and norepinephrine levels therefore tending to alter the cardiovascular circulation. To find how cerebral perfusion changes in the levodopa process among PD patients, both perfusion capacity and spatial patterns computations were performed in this study. The initial conclusion is no obvious evidence supporting that cerebral perfusion alternation was effected in levodopa process. Further investigations were required to validate this point of view.

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