This study aimed to compare the difference of blood perfusion and collateral circulation compensation between symptomatic and asymptomatic patients with severe stenosis or occlusion of unilateral middle cerebral artery (MCA) by using 3D pseudo-continuous arterial spin labeling (pcASL) at two different post labeling delays (PLD) times of 1.5s and 2.5s and territorial pcASL with bilateral internal carotid arteries, ipsilateral external carotid artery and vertebrobasilar artery labelled. 49 patients (26 symptomatic and 23 asymptomatic) were recruited. Compared with symptomatic group, asymptomatic group showed significantly stronger collateral circulation and higher number of patients with secondary collateral circulation opening.
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