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Abstract #3757

Implementation of a Multiparametric MRI Model of Glioma Infiltration for Dose Painting Radiotherapy

Caterina Brighi1,2, David E. J. Waddington1,2, Farhannah Aly2,3,4, Eng-Siew Koh2,3,4, Amy Walker2,3,4, Philip C. de Witt Hamer5,6, Niels Verburg5,6, Lois C. Holloway2,3,4, Brendan Whelan1,2, Cathy Chen3, and Paul J. Keall1,2
1ACRF Image X Institute, Sydney School of Health Science, The University of Sydney, Eveleigh, Australia, 2Medical Physics, Ingham Institute of Applied Medical Research, Liverpool, Australia, 3Liverpool and Macarthur Cancer Therapy Centres, Liverpool, Australia, 4South West Sydney Clinical School, University of New South Wales, Sydney, Australia, 5Brain Tumor Center Amsterdam, Amsterdam University Medical Centre, Amsterdam, Netherlands, 6Department of Neurosurgery, Amsterdam University Medical Centre, Amsterdam, Netherlands


Multiparametric MRI (mpMRI) promises to guide dose painting (DP) radiotherapy to improve local control rates in glioblastoma (GBM) patients. In this study we develop a workflow for DP based on a clinically validated mpMRI model of infiltrative tumour in GBM patients. We demonstrate the repeatability of DP prescriptions, the quality of the resulting DP plans, and that DP can improve modelled local control rates over standard radiotherapy in GBM patients. Our findings provide evidence of technical and clinical validation steps, which are key for the clinical translation of mpMRI-based DP in GBM.

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