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Abstract #3756

Focused ultrasound thalamotomy for the treatment of tremor impacts the cerebello-thalamo-cortical tremor network

Louisa Dahmani1,2, Yan Bai1, Meiling Li2, Lunhao Shen2, Jianxun Ren2, Jianjun Ma1, Danhong Wang2, Lei Du2, Weigang Cui3, Meiyun Wang1, and Hesheng Liu2,3
1Henan Provincial People’s Hospital & People Hospital of Zhengzhou University, Zhengzhou, China, 2Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 3Medical University of South Carolina, Charleston, SC, United States


We used Magnetic Resonance-guided Focused Ultrasound to reduce hand tremor in 13 patients with Parkinson’s disease and essential tremor, by lesioning the ventral intermediate nucleus (VIM) of the thalamus. We also investigated the functional reorganization of the brain after the procedure. We observed a 67% reduction in target hand tremor following the procedure. The regions that showed above-average change in functional connectivity are part of the cerebello-thalamo-cortical tremor network, confirming that lesioning the VIM was successful in targeting this network. We also observed some normalization in the functional connectivity of the target hand motor region, congruent with tremor alleviation.

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