Abstract #3765

To characterize clear cell renal cell carcinoma using diffusion weighted imaging with a fractional order calculus model

Bowen Shi¹, Ke Xue², Yili Yin¹, Qing Xu¹, Binbin Shi¹, Dongmei Wu³, Yongming Dai⁴, and Jing Ye¹

¹Department of Medical Imaging, Clinic Medical School, Yangzhou University, Northern Jiangsu Province Hospital, Yangzhou, China, ²MR Collaboration, Central Research Institute, Shanghai United Imaging Healthcare Co.,Ltd, Shanghai, China, ³Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronics Science, East China Normal University, Shanghai, China, ⁴MR Collaboration, Central Research Institute, Shanghai United Imaging Healthcare, Shanghai, China

Synopsis

Accurately characterizing ccRCC grades with a non-invasive method would be vital for guiding treatment and prognosis. This study evaluated and compared the performance of conventional ADC and the FROC parameters, D_froc, β, μ, in differentiation of low- and high-grade ccRCC. All the FROC parameters showed better diagnostic performance than ADC in characterizing ccRCC grades, among which β yielded the highest AUC value. This implied the clinical potential of the FROC model in evaluating renal tumor aggressiveness and the dominant role of β in probing tumor heterogeneity and microstructural complexity.

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