To characterize clear cell renal cell carcinoma using diffusion weighted imaging with a fractional order calculus model
Bowen Shi1, Ke Xue2, Yili Yin1, Qing Xu1, Binbin Shi1, Dongmei Wu3, Yongming Dai4, and Jing Ye1
1Department of Medical Imaging, Clinic Medical School, Yangzhou University, Northern Jiangsu Province Hospital, Yangzhou, China, 2MR Collaboration, Central Research Institute, Shanghai United Imaging Healthcare Co.,Ltd, Shanghai, China, 3Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronics Science, East China Normal University, Shanghai, China, 4MR Collaboration, Central Research Institute, Shanghai United Imaging Healthcare, Shanghai, China
Accurately characterizing ccRCC grades with a non-invasive method would be vital for guiding treatment and prognosis. This study evaluated and compared the performance of conventional ADC and the FROC parameters, Dfroc, β, μ, in differentiation of low- and high-grade ccRCC. All the FROC parameters showed better diagnostic performance than ADC in characterizing ccRCC grades, among which β yielded the highest AUC value. This implied the clinical potential of the FROC model in evaluating renal tumor aggressiveness and the dominant role of β in probing tumor heterogeneity and microstructural complexity.
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