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Abstract #3775

Developmental pattern of association fibers and their interaction with associated cortical microstructures in 0-5 month-old infants

Tingting Liu1, Yuqing You2, Zhiyong Zhao1, Zuozhen Cao1, Ruike Chen1, Mingyang Li1, Ying Lv3, Mingyan Li3, Fusheng Gao2, Hongxi Zhang2, Chai Ji3, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Department of Child Health, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China


The present study aimed to investigate the spatiotemporal developmental pattern of association fibers in infants aged 0-5 months and the interaction between these fibers and the associated cortex utilizing FBA based on HARDI data. We found that the C-shaped fibers demonstrate an approximately symmetrical along-track pattern with more advanced development in the middle segments than the extremities; the horizontally oriented fibers manifest that the anterior segments started later but developed faster than the posterior segments. Mediation analysis revealed the mediation effect of cortical GM on the development of WM was more prominent than that of WM on GM.

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