Abstract #3776
Effects of low-moderate prenatal alcohol exposure on brain development in childhood
Claire Kelly1,2,3, Thijs Dhollander2, Evelyne Muggli1,4, Jane Halliday4,5, Elizabeth Elliott6,7, Anthony Penington4,8, Alicia Spittle1,9, Della A Forster10,11, Sharon Lewis4,5, Stephen Hearps12, Deanne K Thompson1,2,4, and Peter J Anderson1,3
1Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 3Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia, 4Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 5Reproductive Epidemiology, Murdoch Children's Research Institute, Melbourne, Australia, 6Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia, 7Sydney Children's Hospitals Network, Westmead, Sydney, Australia, 8Royal Children’s Hospital, Melbourne, Australia, 9Department of Physiotherapy, The University of Melbourne, Melbourne, Australia, 10The Royal Women's Hospital, Melbourne, Australia, 11Judith Lumley Centre, La Trobe University, Melbourne, Australia, 12Brain and Mind, Murdoch Children's Research Institute, Melbourne, Australia
Synopsis
Effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied. In a general antenatal population cohort, we compared brain structure between 6-8-year-old children with no PAE (n=41), PAE during trimester 1 (n=44), and PAE throughout gestation (n=58). Most brain regions did not differ between groups, however the caudal anterior cingulate cortex area, and striato-cortical tract cross-sectional area, were significantly smaller in the group exposed to alcohol throughout gestation relative to the other groups. Overall, low-moderate PAE is not strongly associated with brain structure, except low-moderate PAE throughout gestation is associated with specific brain regional alterations.
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