Abstract #3783

Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics

Yuki Matsumoto¹, Yuki Kanazawa¹, Yuki Kinjo², Masafumi Harada¹, Tosiaki Miyati³, Hiroaki Hayashi³, Mitsuharu Miyoshi⁴, Naoki Maeda², Yasuhisa Kanematsu⁵, Yasushi Takagi⁵, and Akihiro Haga¹

¹Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, ²Graduate school of Health Science, Tokushima University, Tokushima, Japan, ³Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ⁴Global MR Applications and Workflow, GE Healthcare Japan, Hino-city, Japan, ⁵Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan

Synopsis

Our purpose was to assess plaque vulnerability under the influence of blood flow in terms of morphological and component characteristics using MRI.Twenty-three patients with symptomatic and asymptomatic carotid stenosis, all of whom provided informed consent, underwent 3T MRI scan (GE Healthcare). We evaluated the consistency between the flow patterns and plaque features in the carotid artery stenosis, using 4D-flow MRI and 3D-FSE-MSDE sequences. During the vulnerability analysis, it was observed that there was a negative correlation between 3D-FSE-MSDE and 4D-flow parameter (R = -0.43, P < 0.001).

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