Evaluation of Blood Flow and Plaque Vulnerability in Carotid Artery Stenosis Focusing on Morphological and Component Characteristics
Yuki Matsumoto1, Yuki Kanazawa1, Yuki Kinjo2, Masafumi Harada1, Tosiaki Miyati3, Hiroaki Hayashi3, Mitsuharu Miyoshi4, Naoki Maeda2, Yasuhisa Kanematsu5, Yasushi Takagi5, and Akihiro Haga1
1Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, 2Graduate school of Health Science, Tokushima University, Tokushima, Japan, 3Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 4Global MR Applications and Workflow, GE Healthcare Japan, Hino-city, Japan, 5Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
Our purpose was to assess plaque vulnerability under the influence of blood flow in terms of morphological and component characteristics using MRI.Twenty-three patients with symptomatic and asymptomatic carotid stenosis, all of whom provided informed consent, underwent 3T MRI scan (GE Healthcare). We evaluated the consistency between the flow patterns and plaque features in the carotid artery stenosis, using 4D-flow MRI and 3D-FSE-MSDE sequences. During the vulnerability analysis, it was observed that there was a negative correlation between 3D-FSE-MSDE and 4D-flow parameter (R = -0.43, P < 0.001).
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