Abstract #3784

Sex-related Changes in GABA+ Signaling in the Right Thalamus in Patients with Knee Osteoarthritis through Acupuncture Stimulation

Nan Gao¹, Sheng Hu^1,2, Xiaoxiao Wang¹, and Bensheng Qiu¹

¹Hefei National Laboratory for Physical Sciences at the Microscale and Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China, ²School of Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, China

Synopsis

This study aimed to investigate GABA variation between KOA patients and healthy people without therapy and how GABA changes through acupuncture stimulation. MEGA-PRESS sequence was used to detect GABA signaling in the right thalamus before and after acupuncture stimulation on EX-LE5 acupoint of the left leg. Our study demonstrated a sex-related GABA+/Cr difference in patients with KOA chronic pain, proving the quantitative sex differences in human pain processing. Moreover, the therapeutic effect of acupuncture stimulation was positively proved and quantified by measuring GABA+/Cr.

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