Striatum-thalamus microstructural alterations in levodopa-induced dyskinesia using four advanced diffusion models
Tingting Yuan1, Ying Zhang2, Hongchao Wang1, Yueluan Jiang3, Chenglong Wang4, Chunjie Guo1, Guang Yang4, and Huiting Zhang3
1Department of Radiology, The First Hospital of Jilin University, Changchun, China, 2Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China, 3MR Scientific Marketing, Siemens Healthineers, Beijing, China, 4Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
The major complication of dopaminergic therapy in Parkinson’s disease (PD) is dyskinesia which affects patients' quality of life. The pathogenesis of levodopa-induced dyskinesia (LID) remains unclear. In this study, we aimed to investigate striatum-thalamus alterations in PD patients with and without LID using advanced diffusion magnetic resonance imaging (dMRI) techniques (DTI, DKI, NODDI and MAP).
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