Abstract #3785

Striatum-thalamus microstructural alterations in levodopa-induced dyskinesia using four advanced diffusion models

Tingting Yuan¹, Ying Zhang², Hongchao Wang¹, Yueluan Jiang³, Chenglong Wang⁴, Chunjie Guo¹, Guang Yang⁴, and Huiting Zhang³

¹Department of Radiology, The First Hospital of Jilin University, Changchun, China, ²Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China, ³MR Scientific Marketing, Siemens Healthineers, Beijing, China, ⁴Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

Synopsis

The major complication of dopaminergic therapy in Parkinson’s disease (PD) is dyskinesia which affects patients' quality of life. The pathogenesis of levodopa-induced dyskinesia (LID) remains unclear. In this study, we aimed to investigate striatum-thalamus alterations in PD patients with and without LID using advanced diffusion magnetic resonance imaging (dMRI) techniques (DTI, DKI, NODDI and MAP).

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