Increased Vascular Permeability of 17O-labeled Water in the Amyotrophic Lateral Sclerosis Model Mice using Indirect Proton MRI
Hiroyuki Kameda1,2, Yuji Komaki3, and Kohsuke Kudo4,5
1Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 2Faculty of Dental Medicine, Department of Radiology, Hokkaido University, Sapporo, Japan, 3Live Imaging Center, Central Institute for Experimental Animals, Kawasaki, Japan, 4Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 5Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Hokkaido University, Sapporo, Japan
We evaluated the increased vascular permeability of 17O-labeled Water in the amyotrophic lateral sclerosis (ALS) mice using indirect proton MRI. The spinal cord of nine ALS mice and ten wild-type (WT) mice were scanned with 7T MRI with the T2-weighted RARE sequence. In the femoral vein, 17O-labeled water was intravenously injected. In ROIs of the spinal cord, the 17O concentration increased more in ALS mice than in the control mice. This latest method can detect the abnormalities in water kinetics probably caused by the impairments in blood–spinal cord barrier of ALS mice.
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