We evaluated the increased vascular permeability of 17O-labeled Water in the amyotrophic lateral sclerosis (ALS) mice using indirect proton MRI. The spinal cord of nine ALS mice and ten wild-type (WT) mice were scanned with 7T MRI with the T2-weighted RARE sequence. In the femoral vein, 17O-labeled water was intravenously injected. In ROIs of the spinal cord, the 17O concentration increased more in ALS mice than in the control mice. This latest method can detect the abnormalities in water kinetics probably caused by the impairments in blood–spinal cord barrier of ALS mice.
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