Abstract #3787

Pseudo-continuous arterial spin labeling reveal altered cerebral hemodynamics and blood-brain barrier dysfunction in CADASIL patients

Jinyuan Zhang^1,2,3, Zihao Zhang^1,2,3, Chen Ling^4,5, Xingfeng Shao⁶, Zhixin Li^1,2,3, Huilou Liang^1,2,3, Jing An⁷, Qi Yang⁸, Rong Xue^1,2,3, Yan Zhuo^1,2,3, Zhaoxia Wang^4,5, Yun Yuan^4,5, and Danny JJ Wang⁶

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, ⁴Department of Neurology, Peking University First Hospital, Beijing, China, ⁵Beijing Key Laboratory of Neurovascular Disease Discovery, Peking University First Hospital, Beijing, China, ⁶Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁷Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁸Department of Radiology, Chaoyang Hospital, Capital Medical University, Beijing, China

Synopsis

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited form of cerebral small vessel disease (cSVD). In this study, we investigated the changes of cerebral blood flow (CBF), arterial transit time (ATT) and water exchange rate (k_w) measured by multi-delay pseudo-continuous arterial spin labeling (pCASL) and diffusion prepared pCASL. Increased ATT and decreased k_w were found in CADASIL patients compared with healthy controls. The results indicated modified cerebral hemodynamics and dysfunction of blood-brain barrier in CADASIL patients. MD-pCASL and DP-pCASL are promising for evaluating hemodynamics and BBB function of cSVD.

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