Pseudo-continuous arterial spin labeling reveal altered cerebral hemodynamics and blood-brain barrier dysfunction in CADASIL patients
Jinyuan Zhang1,2,3, Zihao Zhang1,2,3, Chen Ling4,5, Xingfeng Shao6, Zhixin Li1,2,3, Huilou Liang1,2,3, Jing An7, Qi Yang8, Rong Xue1,2,3, Yan Zhuo1,2,3, Zhaoxia Wang4,5, Yun Yuan4,5, and Danny JJ Wang6
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, 4Department of Neurology, Peking University First Hospital, Beijing, China, 5Beijing Key Laboratory of Neurovascular Disease Discovery, Peking University First Hospital, Beijing, China, 6Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 7Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 8Department of Radiology, Chaoyang Hospital, Capital Medical University, Beijing, China
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited form of cerebral small vessel disease (cSVD). In this study, we investigated the changes of cerebral blood flow (CBF), arterial transit time (ATT) and water exchange rate (kw) measured by multi-delay pseudo-continuous arterial spin labeling (pCASL) and diffusion prepared pCASL. Increased ATT and decreased kw were found in CADASIL patients compared with healthy controls. The results indicated modified cerebral hemodynamics and dysfunction of blood-brain barrier in CADASIL patients. MD-pCASL and DP-pCASL are promising for evaluating hemodynamics and BBB function of cSVD.
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