Abstract #3789

Hyperintense globus pallidus rim sign could be a novel hallmark of Wilson disease at 7T MRI: a pilot case-control study

Su Dongning^1,2, Zhang Zhe^2,3, Zhang Zhijin^1,2, Zhu Wanlin^2,3, Sui Binbin^2,3, Zhang Yingkui^2,3, Bi Jingfeng^2,3, Kong Qingle ^3,4, Gan Yawen^1,2, Yan Rui^1,2, Wang Xuemei^1,2, Wang Zhan^1,2, Wang Yongjun ^1,2,3, Wu Tao^1,2, Jing Jing^1,2,3, and Feng Tao^1,2

¹Department of Neurology, Beijing Tiantan Hospital,Captital Medical University, Beijing, China, ²China National Clinical Research Center for Neurological Diseases, Beijing, China, ³Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴MR Collaboration, Siemens Healthineers Ltd., Beijing, China

Synopsis

To explore specific neuroimaging characteristics of iron deposition in WD, we conducted a small sample, prospective case-control study to compare the 7T MRI manifestation of iron deposition in the basal ganglia among PD, WD patients and healthy controls. The hyperintense globus pallidus rim sign could be a specific neuroimaging characteristic of WD in 7T T2*-weighted and SWI images, which may be related to the unique iron deposition pattern in the striatum in WD patients. Internal capsule appears to be hyperintensity with a clear border only observed in WD patients. These findings have the potential to provide diagnostic biomarkers for WD.

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