To explore specific neuroimaging characteristics of iron deposition in WD, we conducted a small sample, prospective case-control study to compare the 7T MRI manifestation of iron deposition in the basal ganglia among PD, WD patients and healthy controls. The hyperintense globus pallidus rim sign could be a specific neuroimaging characteristic of WD in 7T T2*-weighted and SWI images, which may be related to the unique iron deposition pattern in the striatum in WD patients. Internal capsule appears to be hyperintensity with a clear border only observed in WD patients. These findings have the potential to provide diagnostic biomarkers for WD.
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